Test, Test

Profile Picture

Filters

2011 - 20132
Reset filters

Settings

Citations

Publication Search Results

Now showing 1 - 3 of 3
  • No Thumbnail Available
    Publication
    Immunological and Viral Determinants of Dengue Severity in Hospitalized Adults in Ha Noi, Viet Nam
    (2011-03-01) Simmons, Cameron; Test, Test; Parthasarathy, Prabha
    BACKGROUND: The relationships between the infecting dengue serotype, primary and secondary infection, viremia and dengue severity remain unclear. This cross-sectional study examined these interactions in adult patients hospitalized with dengue in Ha Noi. METHODS AND FINDINGS: 158 patients were enrolled between September 16 and November 11, 2008. Quantitative RT-PCR, serology and NS1 detection were used to confirm dengue infection, determine the serotype and plasma viral RNA concentration, and categorize infections as primary or secondary. 130 (82%) were laboratory confirmed. Serology was consistent with primary and secondary infection in 34% and 61%, respectively. The infecting serotype was DENV-1 in 42 (32%), DENV-2 in 39 (30%) and unknown in 49 (38%). Secondary infection was more common in DENV-2 infections (79%) compared to DENV-1 (36%, p<0.001). The proportion that developed dengue haemorrhagic fever (DHF) was 32% for secondary infection compared to 18% for primary infection (p = 0.14), and 26% for DENV-1 compared to 28% for DENV-2. The time until NS1 and plasma viral RNA were undetectable was shorter for DENV-2 compared to DENV-1 (p≤0.001) and plasma viral RNA concentration on day 5 was higher for DENV-1 (p = 0.03). Plasma viral RNA concentration was higher in secondary infection on day 5 of illness (p = 0.046). We didn't find an association between plasma viral RNA concentration and clinical severity. CONCLUSION: Dengue is emerging as a major public health problem in Ha Noi. DENV-1 and DENV-2 were the prevalent serotypes with similar numbers and clinical presentation. Secondary infection may be more common amongst DENV-2 than DENV-1 infections because DENV-2 infections resulted in lower plasma viral RNA concentrations and viral RNA concentrations were higher in secondary infection. The drivers of dengue emergence in northern Viet Nam need to be elucidated and public health measures instituted.
  • No Thumbnail Available
    Publication
    Excited Heavy Mesons From Lattice QCD
    (American Institute of Physics Publishing, 25/05/16) Thomas, Christopher; Test, Test; Parthasarathy, Prabha; Systemic Physiological and Ecotoxicological Research (SPHERE)
  • Thumbnail Image
    Publication
    Our Economy: Towards a new prosperity
    (Oxfam GB, 2013-06-20) Trebeck, Katherine; Francis, Stuart; Test, Test; Parthasarathy, Prabha
    For too many Scots, the existing economic model is failing. Far from improving their lives, it traps them in a cycle of economic hardship. Yet it is possible to overcome poverty, both in Scotland and across the UK - many of the solutions already exist, hidden within the very communities hit hardest by an economic model that worships at the altar of ‘economic growth’. The extraordinary work of our partners in Scotland has helped frame this report, where we hope to show how allocating resources in a more effective and sustainable way can deliver lasting change. In this paper we argue that the Scottish economy must pursue policies which deliver for the people, and policy-makers must play a central and driving role as underwriters of community solutions. Some of our recommendations include: - Build on the National Performance Framework and the Oxfam Humankind Index to create a better way of measuring our collective prosperity. - Create a Poverty Commissioner to ensure spending decisions are poverty proofed and to support communities to challenge Government policies and private sector actions that do not contribute to socio-economic equality. - Employers in the public and private sectors should pay a living wage. - Tax havens, offshore earnings and loopholes which allow avoidance, should be pursued and closed. Business support, corporate social responsibility awards and government plaudits should be contingent on companies meeting their tax obligations. - A Sustainable Livelihoods Approach (SLA) to social protection should be pursued. This would recognise complex barriers to work, gender differences and caring responsibilities as well as rewarding individuals’ range of skills and contributions (including activities that deliver social benefit but are currently insufficiently valued by the market). - Funding is required to make it easier for deprived communities to own assets for local benefit. As part of a socio-economic duty, council staff should support deprived communities prepare for ownership, with upfront grants enabling communities to assess the merits of an opportunity.